The Science Behind
Your Health Overview
ExaHealth combines laboratory results, wearable data, and medical imaging into a unified health overview — powered by peer-reviewed research and clinical guidelines used by healthcare professionals worldwide.
Your Complete Health Data, Unified
Most health platforms organize labs or wearable data. ExaHealth is the first to combine all three data sources into one unified overview.
Laboratory Tests
Upload reports from any lab
Wearable Vitals
Connect Apple Watch, Oura, & more
Medical Imaging
Add imaging reports
One Unified Health Overview
All your health data organized together, surfacing trends that would be hard to see from any single source alone.
How Your Score is Calculated
A transparent, five-step process that transforms your health data into actionable insights.
Collect
We gather data from your lab reports, wearable devices, and medical imaging - building a complete picture of your health.
Upload lab reports, connect Apple Watch or Oura Ring, add imaging results
Analyze
Our system maps each value to evidence-based reference ranges from peer-reviewed clinical studies.
Every threshold backed by published research and clinical guidelines
Personalize
Your results are adjusted based on your age, sex, and any health conditions you've selected.
Life stage personalization ensures relevant, actionable insights
Score
Each health dimension receives a score reflecting how your markers compare to optimal ranges.
Weighted scoring prioritizes the most clinically significant markers
Guide
You receive clear insights highlighting what's working and what needs attention.
Actionable recommendations to discuss with your healthcare provider
Grounded in Clinical Research
Every reference range in our system is derived from peer-reviewed meta-analyses, large cohort studies, and clinical practice guidelines. We don't use arbitrary cutoffs - our thresholds reflect real-world health outcomes from studies involving millions of participants.
14 Health Categories
Each category is organized using established medical methodologies and validated reference ranges from leading health organizations.
Heart Health
Comprehensive cardiovascular overview combining lipid profiles, cardiac markers, and imaging findings
Key markers:
Total Cholesterol • LDL • HDL • Triglycerides • ApoB • Lp(a) • hs-CRP • Homocysteine • Blood Pressure • HRV
Metabolism
Blood sugar control, insulin sensitivity, and metabolic syndrome evaluation
Key markers:
Fasting Glucose • HbA1c • Fasting Insulin • HOMA-IR • C-Peptide • Triglycerides • BMI
Liver Health
Liver enzyme analysis, function markers, and hepatic imaging assessment
Key markers:
ALT • AST • ALP • GGT • Bilirubin • Albumin • Total Protein • Fatty Liver Grade
Kidney Function
Renal function markers including eGFR staging and kidney imaging
Key markers:
Creatinine • eGFR • BUN • Uric Acid • Cystatin C • ACR • Microalbumin • Blood Pressure
Thyroid
Thyroid hormone balance, antibody markers, and ultrasound findings
Key markers:
TSH • Free T4 • Free T3 • Total T4 • TPO Antibodies • Thyroglobulin Ab • TIRADs
Bone Health
Bone density assessment, mineral status, and fracture risk evaluation
Key markers:
Vitamin D • Calcium • Phosphorus • PTH • ALP • Magnesium • DEXA T-Score
Blood Health
Complete blood count analysis and oxygen-carrying capacity assessment
Key markers:
Hemoglobin • RBC • WBC • Platelets • Hematocrit • MCV • MCH • RDW • SpO2
Inflammation
Chronic inflammation markers and immune system function analysis
Key markers:
hs-CRP • ESR • Fibrinogen • IL-6 • Procalcitonin • WBC • NLR • Ferritin
Hormones
Sex hormones, adrenal function, and endocrine balance assessment
Key markers:
Testosterone • Free Testosterone • DHEA-S • Cortisol • SHBG • Estradiol • FSH • LH • Prolactin
Nutrition
Essential vitamin and mineral status evaluation
Key markers:
Vitamin B12 • Iron • Ferritin • Folate • Vitamin D • TIBC • Transferrin Sat • Zinc • Magnesium
Brain & Cognition
Cognitive health markers, neuroimaging, and brain health indicators
Key markers:
Homocysteine • HRV • Vitamin B12 • Folate • Vitamin D • hs-CRP • TSH • Sleep REM%
Sleep Quality
Sleep duration, architecture, and quality metrics combined with related biomarkers
Key markers:
Sleep Duration • Deep Sleep % • REM Sleep % • Sleep Quality • HRV • Resting HR • Magnesium • Vitamin D • Ferritin • Cortisol • TSH
Fitness
Exercise recovery, HRV analysis, and athletic performance markers
Key markers:
Resting Heart Rate • HRV • Creatine Kinase • Testosterone • Ferritin • Iron • Vitamin D • Hemoglobin • Cortisol
Gut Health
Digestive health markers and nutrient absorption indicators
Key markers:
Fecal Calprotectin • H. Pylori • Stool Occult Blood • Amylase • Lipase • Albumin • Vitamin B12 • Iron
Not All Biomarkers Are Created Equal
Our scoring system reflects what decades of medical research have proven: some markers matter more than others when it comes to your long-term health outcomes.
Grounded in Epidemiological Research
Population-Scale Studies
Our weighting methodology is derived from landmark longitudinal studies - Framingham Heart Study, UK Biobank, NHANES, and others - involving millions of participants tracked over decades.
Hazard Ratio Integration
Each biomarker's clinical significance is informed by its hazard ratio - how strongly deviations from optimal correlate with adverse health events in peer-reviewed research.
Outcome-Driven Prioritization
Markers with stronger associations to morbidity and mortality outcomes carry proportionally greater influence in your health scores - ensuring your attention is directed where it matters most.
How Clinical Significance Impacts Your Score
e.g., HbA1c, LDL-C, Blood Pressure
Strongest mortality/morbidity associations
e.g., Ferritin, Vitamin D, TSH
Significant health outcome correlations
e.g., MCV, MCH, indirect indicators
Contextual and confirmatory value
Illustrative representation - actual weights are derived from clinical research
Framingham Heart Study
Cardiovascular risk factors and lipid significance
UK Biobank
Multi-system biomarker associations
NHANES
Population health norms and metabolic markers
Science-Driven, Not Arbitrary
Every weighting decision in our system traces back to published research. When we say a marker “matters more,” it's because epidemiological evidence shows its deviation has a statistically significant relationship with health outcomes. This isn't guesswork - it's applied clinical science.
Your Health Context Matters
What's optimal for one person may not be optimal for another. ExaHealth adjusts reference ranges and marker priorities based on your specific health context.
Pregnancy
Trimester-specific ranges for prenatal health monitoring
Menopause
Adjusted ranges for hormonal transition and bone health
Senior Health
Age-appropriate ranges and kidney function considerations
Thyroid Conditions
Condition-specific TSH targets and related marker adjustments
Diabetes Care
Enhanced glucose monitoring and complication screening
Heart Conditions
Intensified cardiovascular risk factor management
Validated Clinical Risk Calculators
We don't invent risk scores - we implement the same validated calculators used by physicians worldwide, backed by decades of research on millions of patients.
ASCVD Risk Score
Pooled Cohort Equations
10-year risk of first atherosclerotic cardiovascular event (heart attack, stroke)
Key Inputs:
Framingham Risk
Cardiovascular Disease Risk
10-year cardiovascular risk using the gold-standard from 75+ years of research
Key Inputs:
KDIGO CKD Risk
Kidney Disease Classification
Chronic kidney disease staging and progression risk using GFR and albuminuria
Key Inputs:
Diabetes Risk
FINDRISC-Based Assessment
Type 2 diabetes risk estimation using metabolic and lifestyle factors
Key Inputs:
FRAX® Fracture Risk
WHO Fracture Risk Assessment
10-year probability of major osteoporotic and hip fractures
Key Inputs:
Biological Age
PhenoAge Algorithm
Physiological age vs chronological age based on 9 blood biomarkers
Key Inputs:
The Same Tools Your Doctor Uses
These aren't proprietary black boxes - they're peer-reviewed, clinically validated risk calculators published in journals like Circulation and JAMA. When you see a 10-year ASCVD risk of 12%, it means exactly what it would mean in your cardiologist's office.
Never Miss a Critical Test
Our system tracks your biomarker history and automatically calculates when your next tests are due - adjusting frequency based on your values, conditions, and clinical guidelines.
Guideline-Based Frequencies
ADA, ACC/AHA, KDIGO, and 40+ other guidelines inform test intervals
Dynamic Adjustments
Abnormal values trigger more frequent monitoring automatically
Condition-Specific
Diabetes, CKD, thyroid conditions each have tailored schedules
Urgency Prioritization
Critical, overdue, upcoming - know what needs attention first
Your Test Schedule
Diabetes care - recommended every 3 months
Annual screening - last tested 11 months ago
Monitoring deficiency treatment - every 6 months
Stable hypothyroid - annual check sufficient
Illustrative example - your schedule is personalized
Your Health is Interconnected
Health dimensions don't exist in isolation. We analyze 26+ established clinical correlations to show how improving one area creates cascading benefits across your entire system.
Causes
One condition directly leads to another through established biological mechanisms
Example:
Metabolic dysfunction → Fatty liver disease
Worsens
An existing condition accelerates the progression of another
Example:
Cardiovascular issues → Accelerated kidney decline
Improves
Addressing one area creates positive effects in connected dimensions
Example:
Thyroid optimization → Better cardiovascular markers
Key Clinical Correlations We Track
Hyperglycemia damages blood vessels, accelerates atherosclerosis
Fluid retention and hypertension create feedback loop
Hypothyroidism slows metabolism, promotes insulin resistance
Chronic inflammation accelerates plaque formation
CKD impairs vitamin D activation, causing bone loss
NAFLD promotes atherogenic dyslipidemia
Cascade Effect Prediction
When we identify a “root cause” dimension affecting multiple others, we show you the expected timeline for improvements - helping you understand that fixing metabolic health today may improve liver, kidney, and cardiovascular markers in 3-6 months.
Biological Age Analysis
Based on PhenoAge Algorithm
Chronological
55
Biological
52
3 years younger than your calendar age
Contributing Factors:
Illustrative example
Your Body's True Age
Calendar age is just a number. Biological age - calculated from your actual biomarkers - reveals whether your body is aging faster or slower than expected.
9 Blood Biomarkers
Albumin, creatinine, CRP, hemoglobin, MCV, RDW, WBC, ALP, lymphocyte %
NHANES-Validated Model
PhenoAge algorithm trained on mortality data from the National Health and Nutrition Examination Survey
Actionable Insights
See which biomarkers are adding or subtracting years, so you know exactly what to focus on
Published Research: Levine et al. “An epigenetic biomarker of aging for lifespan and healthspan” Aging (Albany NY), 2018. DOI Link
What Healthcare Professionals Say
Healthcare professionals who have reviewed our methodology share their perspective on ExaHealth's evidence-based approach to health scoring.
Dr. Sarah Chen, MD, PhD
Internal Medicine Physician
Stanford Medicine
Preventive Health
“ExaHealth brings the rigor of academic medicine to personalized health tracking.”
Prof. Michael Roberts, PhD
Biostatistician
Harvard T.H. Chan School
Epidemiology
“The evidence-based approach to health scoring is truly groundbreaking.”
Dr. Priya Sharma, MD
Endocrinologist
AIIMS New Delhi
Metabolic Health
“Finally, a platform that understands the nuances of individual health contexts.”
Dr. James Mitchell, MD, MPH
Cardiologist
Johns Hopkins Medicine
Preventive Cardiology
“The cardiovascular risk assessment rivals what we use in clinical practice.”
These quotes represent individual professional opinions based on methodology review. ExaHealth's insights are for informational purposes only and do not constitute medical advice. Always consult your personal healthcare provider for medical decisions.
Clinical-Grade Methodology
ExaHealth is designed to complement clinical care, not replace it. Our methodology aligns with the guidelines you already trust.
Guideline-Aligned
Reference ranges from ACC/AHA, ADA, KDIGO, and other authoritative sources
Evidence-Based
Severity classifications derived from meta-analyses and large cohort studies
Longitudinal Tracking
Visualize trends over time to identify patterns and treatment responses
Comprehensive View
Labs, vitals, and imaging unified in a single health dashboard
Guidelines We Reference
Interested in research collaboration or clinical integration?
Contact Our Medical TeamTrusted by Leading Organizations
Our methodology is built on guidelines from the world's most respected health institutions
WHO
World Health Organization
AHA
American Heart Association
ADA
American Diabetes Association
ICMR
Indian Council of Medical Research
KDIGO
Kidney Disease: Improving Global Outcomes
ATA
American Thyroid Association
Ready to Understand Your Health?
Join thousands who are taking control of their health with evidence-based insights. Your first health score is free.
Important Note
ExaHealth scores are for informational purposes only and do not constitute medical diagnosis or treatment advice. Always consult qualified healthcare professionals for medical decisions. Our platform is designed to complement, not replace, the care you receive from your doctor.